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Hydroxocobalamin: Medical Uses, Dosage, and Side Effects - Faces

Baird, G., Douglas, H

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Select Vitamin C Dose:25g

Results from an in vitro study demonstrate that gp120 and methamphetamine (MA) may cause apoptotic cell death by inducing oxidative stress through NADPH oxidase (NOX) and other pathways in primary and SVGA astrocytes and such effects could be further confirmed by inhibiting NADPH‐derived ROS generation using NOX specific inhibitor or siRNA.113 In an in vitro hypoosmotic swelling model, the amount of ROS produced by NADPH oxidase is found to increase significantly in astrocytes.99 On the contrary, oxidative stress is known to cause astrocyte swelling which contributes largely to the whole brain oedema.52 To sum up, NADPH oxidase significantly affects the physiological function of astrocytes and more attention should be paid to astrocytic NADPH oxidative stress when it comes to seeking new methods to modulate NOX activity in the CNS