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Klebsiella pneumoniae: a connecting link in the One Health concept - PMC

Melatonin exerts anti-inflammatory activity by binding to macrophages and lymphocytes, blocking the transcriptional factors that trigger proinflammatory cytokines including hypoxia-inducible factor (HIF), nuclear factor Erythroid2-related factor 2 (NRF2), cyclic adenosine monophosphate (cAMP), cAMP response element binding protein (CREB), signal transducer and activator of transcription (STAT), peroxisome proliferator-activated receptors (PPARs) and activator protein-1 (AP-1) [31]

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A hallmark of innate immune recognition is PRR diversity, which reflects both the coexistence of multiple receptor families sensing distinct microbial classes and the ability of individual receptors, such as TLR4, to recognize more than one ligand, including bacterial LPS and selected viral proteins