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glutathione s transferase omega 1 1-1 (GSTO1-1) can effect the inter-cell transfer of cisplatin resistance through the exosomal route glutathione s transferase
Effect of pH on enzyme activity - Revise: Proteins - National 5 Biology Revision - BBC Bitesize
FOXO4-DRI acts as a competitive inhibitor of this interaction — binding directly to the transactivation domain 2 (TAD2) of p53, displacing FOXO4, and allowing phosphorylated p53 to be exported from the nucleus and directed to mitochondria, where it activates BAX, triggers caspase-3 cleavage (via the p53/BCL-2/Caspase-3 signalling pathway), and drives cell-intrinsic apoptosis
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These peptides may also contain an amide at the C-terminal to reduce the action of carboxypeptidases
expressed in Escherichia coli
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